Engineering Microbes to Rewire Host-Microbiome Interactions
Speaker
 | Matthew CHANG Dean’s Chair Associate Professor Synthetic Biology Translational Research Programme and Department of Biochemistry, Yong Loo Lin School of Medicine National University of Singapore, Singapore |
Talk Abstract
Recent advances in understanding the composition of the human microbiota and its essential roles in health and disease have significantly accelerated the development of therapeutic strategies. Additionally, advancements in synthetic biology have enabled the design of programmable genetic circuits and the reprogramming of cells, paving the way for novel microbiota-based interventions. This presentation will detail our latest progress in engineering commensal microbes into multifunctional platforms with clinically relevant functionalities. Specifically, I will emphasize our efforts to transform these microbes into autonomous therapeutic agents capable of modulating microbiome environments in vivo, targeting infections, metabolic disorders, and cancers. Our research establishes a robust foundation for using engineered microbes to rewire host-microbiome interactions and highlights the potential of microbial engineering strategies as clinical